Author Archives: jchoigt

About jchoigt

I'm an Associate Professor in the School of Biology at Georgia Tech, and Faculty Coordinator of the Professional MS Bioinformatics degree program.

Flipping a large Intro Bio class – round 2

After reviewing results and student responses to my first iteration of flipping my large Intro Biological Principles class last fall, I made a few revisions for this go-round. The #1 student complaint from last fall was that watching the 30+ … Continue reading

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What might geology be telling us about the fossil record?

One of the themes of our evolution module is that the geosphere and biosphere co-evolved throughout Earth history. Evolution of life profoundly affected the geochemistry of the planet, and changing geological conditions in turn repeatedly stirred the pot of evolution. … Continue reading

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An idea for an untextbook for intro biology

Having reviewed significant parts of both standard textbooks and the recent on-line texts by Nature and OpenStax, I’m convinced that we need a radical departure. I call it the “untextbook”. I even have a title: An Evolutionary Framework for Biology. … Continue reading

Posted in Teaching and learning biology | 4 Comments

Working with 23andMe exome data: my CF allele and the need for verification

In my previous post, I described the summary report that accompanied my 23andMe exome sequence data, with summary statistics and the filtering scheme used to arrive at a list of 21 rare, moderate-to-high predicted impact variants. Here I will show … Continue reading

Posted in human genetics | 2 Comments

A first look at my exome variants from 23andMe

About 5 months after I sent my saliva to 23andMe, I received an email that my exome results were ready. The data were in a large (4.2 GB) encrypted file folder, that could be opened only after I had downloaded … Continue reading

Posted in human genetics | 23 Comments

Did Life Begin with “RNA on Steroids”?

The “RNA world” hypothesis posits that life, and biological evolution, began with self-replicating RNA molecules. Before DNA, before protein enzymes, RNA molecules both stored hereditary information, and performed the catalytic functions required for replication. All cells today still depend on … Continue reading

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Cell Membrane Permeability – a Teaching Tidbit from SERSI12

This summer I was privileged to be the facilitator for the Cell/Development group at the Southeast Regional Summer Institute (SERSI), one of 7 replicate progeny of the National Academies/HHMI Summer Institute for advancing undergraduate biology teaching in the nation’s research … Continue reading

Posted in Teaching and learning biology, Teaching Tidbit | Tagged , , , , | 1 Comment